Endocrine Abstracts

Introduction: 11-Hydroxylase deficiency is a rare form of congenital adrenal hyperplasia characterized by glucocorticoid deficiency, hypertension, hypokalemia and virilization in females. We report a case of congenital adrenal hyperplasia due to 11beta-hydroxylase deficiency revealed by bilateral papilledema in the context of arterial hypertension.Case report: A 13-year-old patient, with no medical history, presented with complains of headache, vomiting ...

Introduction: Graves’ ophthalmopathy, also called Graves’ orbitopathy, is a potentially sight-threatening ocular disease that has puzzled physicians and scientists for nearly two centuries. Generally occurring in patients with hyperthyroidism or a history of hyperthyroidism due to Graves’ disease, Graves’ ophthalmopathy is also known as thyroid-associated ophthalmopathy or thyroid eye disease, because it sometimes occurs in patients with euthyroid or hypoth...

Introduction: Osteoporosis is a generalized skeletal disease that combines a decrease in bone density with changes in bone microarchitecture. The bone is abnormally fragile and therefore the risk of fracture is high. We report the case of osteoporosis in a young woman secondary to type 1 diabetes mellitus (T1DM).Case Report: Patient A.M, 26 years old, with a history of polyglandular autoimmune syndrome type 3 since the age of 12, associating T1DM and Has...

Introduction: The diagnosis of insulinomas is made biochemically. However, proper localization of insulinomas is essential before surgery. Therefore, we aimed to evaluate the role of different imaging techniques in the localization of insulinomas. Case series: This case series include 10 patients with biochemically proven insulinomas. The age, gender, results of MRI, CT, EUS, are shown in Table-1. In imaging investigations, abdominal ultrasonography (AU)...

Introduction: Insulinoma is a rare neuroendocrine tumor with an incidence of 1 to 4 per million person-years. It is the most frequent endocrine tumor of the pancreas and is revealed by a spontaneous hypoglycemia. This study aimed to determine the clinical characteristics, diagnostic workup, and outcome of patients with insulinoma.Methods: This is a descriptive, retrospective study including patients with confirmed insulinoma collected over a 32-year peri...

Introduction: Multiple endocrine neoplasia type 2 is an inherited syndrome characterized by the characteristic combination of medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism. We report one case with phenotype-genotype mismatch.Observation: Patient A. T is 45 years of age with a family history of thyroid bone marrow cancer (CMT) and sister brain cancer, father colon cancer, with no personal history of disease. A 60 mm long-axis ...

Background and Aims: Cardiometabolic comorbidity is a well-established complication related to GH hypersecretion. Several studies have highlighted an increased cardiovascular risk in this population. The objective of the current work was to investigate the cardiovascular complications in Tunisian patients diagnosed with acromegaly.Patients and Method: We conducted a retrospective study that included all patients diagnosed with acromegaly who have been fo...

Introduction: Acromegaly is a chronic, slowly progressing disease caused in most cases by growth hormone (GH)- producing pituitary adenoma. This rare disorder is associated with a spectrum of various clinical manifestations and treatment outcomes differ between patients. The aim of this study was to evaluate the impact of adenoma size on comorbidities and biochemical status at the diagnosis of disease.Methods: This is a one-centre cohort study conducted ...

Background and Aims: Acromegaly is a rare condition caused by an excessive secretion of growth hormone (GH) and insulin-like growth factor1 (IGF-1), which are responsible for exaggerated somatic growth and distorted proportions. The objective of the current work was to investigate the clinical and demographic features of acromegaly in Mediterranean patients.Patients and Method: From 1997 to 2021, 29 patients with acromegaly were diagnosed and followed up...

Background and Aims: Acromegaly is an insidious disease related to hypersecretion of growth hormone (GH) that leads to several cardiovascular, respiratory, and metabolic comorbidities. The onset of dysmorphic body changes is one of the earliest signs of this condition. The objective of the current work was to describe the clinical manifestations of dysmorphic modifications characterizing Mediterranean patients diagnosed with acromegaly.Patients and Metho...